THE STATTIC DIARIES

TAK-243 preferentially bound to UBA1 about the relevant E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 lowered amounts of ubiquitylated proteins, enhanced markers of proteotoxic strain and DNA damage tension. In vivo, TAK-243 reduced leukemic stress and targeted leukemic stem cells without proof of toxicity. La